PLXND1

Across TCGA pan-cancer cohorts, PLXND1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PLXND1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PLXND1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLXND1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where PLXND1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLXND1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.409	<.001	12	view →
KIRC	Female	All	+1.939	<.001	12	view →
COAD	All	All	+0.575	<.001	10	view →
LIHC	Female	II,III,IV	+2.482	<.001	8	view →
STAD	Male	II,III,IV	+1.720	<.001	8	view →
THCA	Male	All	+1.265	<.001	8	view →
LUSC	Male	All	−1.094	<.001	6	view →
CHOL	All	All	+2.038	<.001	5	view →
READ	Male	All	+1.756	.008	4	view →
LUAD	All	All	−0.421	.002	4	view →
ESCA	All	All	+1.737	<.001	2	view →
UCEC	All	All	−1.310	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PLXND1–HNSC

Open the HNSC breakdown →