Across TCGA cell cohorts, PLXNB3 mutation is significantly associated with the RNA expression of many other genes, with 619 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLXNB3-associated genes across cancer lineages are MROH5, CCDC116, and PPIL6. Each is linked with PLXNB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLXNB3-to-partner and partner-to-PLXNB3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNB3→partner) and Y-score (partner→PLXNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MROH5 →	+0.015	+3.930	<.001	.001	3	2
BLOOD_Leukemia	CCDC116 →	+0.555	+3.231	<.001	.007	3	2
LARGE_INTESTINE	PPIL6 →	+0.648	+3.169	.005	.009	3	2
BLOOD_Leukemia	BCDIN3D →	+0.507	+3.351	.001	.003	3	2
BLOOD_Leukemia	KHDC3L →	+0.104	+2.359	.002	.007	3	2
BLOOD_Leukemia	C13orf42 →	+0.033	+2.493	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 619 associations by consensus.

Exploration

PLXNB3 survival (RNA) · tumor vs normal (RNA) · all PLXNB3 data types