PLXNB1

Across TCGA patient cohorts, PLXNB1 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLXNB1-associated genes across cancer lineages are Cyclin-E2, ERK2, and Bad_pS112. Each is linked with PLXNB1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLXNB1-to-partner and partner-to-PLXNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by PLXNB1-low versus PLXNB1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNB1→partner) and Y-score (partner→PLXNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-E2 →	+0.220	+3.021	.001	.018	2	5
SKCM	ERK2 →	+0.150	+1.754	.047	.047	3	4
STAD	Bad_pS112 →	-0.287	-2.978	.008	.036	3	3
UCEC	4E-BP1 →	+0.264	+1.999	<.001	.008	3	3
COAD	ASNS →	+0.332	+1.874	.024	.049	3	3
STAD	FASN →	+0.531	+2.823	.013	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Cyclin-E2 by PLXNB1 expression — STAD

Explore this box plot interactively →