PLTP

Across TCGA patient cohorts, PLTP mutation is significantly associated with the RNA expression of many other genes, with 1,417 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLTP-associated genes across cancer lineages are MIR4753, MIR4716, and MIR5008. Each is linked with PLTP in more than 1 cancer types. Because this analysis shows association rather than direction, both PLTP-to-partner and partner-to-PLTP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4753 grouped by PLTP-low versus PLTP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLTP→partner) and Y-score (partner→PLTP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR4753 →	+0.612	+5.542	<.001	<.001	3	2
COAD	MIR4716 →	+0.545	+5.547	<.001	.002	3	2
COAD	MIR5008 →	+0.386	+4.516	<.001	.009	3	2
COAD	MIR6504 →	+0.631	+4.516	.003	.009	3	2
UCEC	H4C7 →	+0.200	+2.077	<.001	.003	3	2
SKCM	RN7SKP42 →	+0.115	+3.869	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,417 associations by consensus.

MIR4753 by PLTP expression — COAD

Explore this box plot interactively →