PLTP

Across TCGA pan-cancer cohorts, PLTP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PLTP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLTP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLTP is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KIRC, KICH, and BLCA are the cancer types where PLTP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLTP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.464	.012	8	view →
KICH	All	II,III,IV	−2.692	<.001	7	view →
BLCA	All	III,IV	−1.127	.005	7	view →
LUAD	All	All	+0.713	<.001	7	view →
BRCA	All	II,III,IV	−1.439	<.001	6	view →
LUSC	All	All	+0.897	<.001	6	view →
KIRP	All	All	+1.342	<.001	5	view →
HNSC	Male	All	+0.948	.001	5	view →
PRAD	All	All	−0.610	.001	2	view →
UCEC	All	All	−0.522	.037	2	view →
CHOL	Female	All	+1.089	.046	1	view →
COAD	Male	III,IV	+0.900	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PLTP–KIRC

Open the KIRC breakdown →