PLTP

Across TCGA cell cohorts, PLTP mutation is significantly associated with the RNA expression of many other genes, with 202 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLTP-associated genes across cancer lineages are GATA5, SLC22A25, and RD3. Each is linked with PLTP in more than 1 cancer types. Because this analysis shows association rather than direction, both PLTP-to-partner and partner-to-PLTP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA5 grouped by PLTP-low versus PLTP-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLTP→partner) and Y-score (partner→PLTP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GATA5 →	+0.011	+4.191	<.001	.007	3	1
BLOOD_Lymphoma	SLC22A25 →	+0.087	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	RD3 →	+0.006	+4.350	.006	.005	3	1
BLOOD_Lymphoma	FAM237A →	+0.019	+4.643	<.001	.005	3	1
BLOOD_Leukemia	DEFB125 →	+0.044	+5.060	<.001	.001	3	1
BLOOD_Leukemia	SCGB1C1 →	+0.098	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 202 associations by consensus.

GATA5 by PLTP expression — BLOOD_Lymphoma

Explore this box plot interactively →