Across TCGA patient cohorts, PLET1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLET1-associated genes across cancer lineages are 14-3-3_beta, CD31, and ACC_pS79. Each is linked with PLET1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLET1-to-partner and partner-to-PLET1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLET1→partner) and Y-score (partner→PLET1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.129	-2.979	.020	.036	3	1
UCEC	CD31 →	-0.186	-3.169	.021	.020	3	1
UCEC	ACC_pS79 →	+0.408	+3.169	.032	.020	2	1
UCEC	SETD2 →	-0.247	-3.169	.039	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

PLET1 survival (RNA) · tumor vs normal (RNA) · all PLET1 data types