Across TCGA pan-cancer cohorts, PLET1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PLET1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PLET1 RNA is repressed in tumor relative to normal tissue. In most cancer types PLET1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, BRCA, and UCEC are the cancer types where PLET1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLET1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.072	.002	7	view →
BRCA	All	III,IV	−0.083	.003	2	view →
UCEC	All	All	−0.076	.028	2	view →
READ	All	All	−0.050	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PLET1 RNA expression & survival · all PLET1 data types