PLEKHG6

Across TCGA patient cohorts, PLEKHG6 protein abundance is significantly associated with the protein abundance of many other proteins, with 3,456 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLEKHG6-associated proteins across cancer lineages are RPS6KA5, RSF1_S1310, and SAMD4B_S592. Each is linked with PLEKHG6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHG6-to-partner and partner-to-PLEKHG6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHG6 versus RPS6KA5 in HNSC, with a Pearson correlation of -0.40.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG6→partner) and Y-score (partner→PLEKHG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPS6KA5 →	-0.384	-0.599	.001	.004	3	1
HNSC	RSF1_S1310 →	-0.681	-0.479	.001	<.001	3	1
HNSC	SAMD4B_S592 →	+0.389	+0.502	.001	<.001	3	1
HNSC	SIN3A_T1111 →	-1.019	-0.741	<.001	<.001	3	1
HNSC	SORBS2_S1018 →	+0.775	+0.543	.001	.002	3	1
HNSC	TJP1_S1619 →	+0.527	+0.577	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,456 associations by consensus.

PLEKHG6 vs RPS6KA5 — HNSC

Explore this scatter interactively →