PLEKHG6

Across TCGA pan-cancer cohorts, PLEKHG6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PLEKHG6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PLEKHG6 RNA is repressed in tumor relative to normal tissue. In most cancer types PLEKHG6 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, LUAD, and KICH are the cancer types where PLEKHG6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLEKHG6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.901	<.001	10	view →
LUAD	Male	II,III,IV	+1.666	<.001	9	view →
KICH	Female	All	−1.154	<.001	9	view →
HNSC	Female	IV	−2.094	.002	8	view →
LUSC	Male	All	+2.476	<.001	7	view →
UCEC	All	All	+1.630	<.001	6	view →
BRCA	All	All	−0.918	<.001	6	view →
CHOL	All	All	+2.557	<.001	5	view →
KIRC	Male	All	+0.484	.001	5	view →
LIHC	All	All	+0.525	.002	4	view →
BLCA	Male	III,IV	+2.688	.016	3	view →
STAD	All	All	+1.138	.014	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PLEKHG6–COAD

Open the COAD breakdown →