PLEKHG4B

Across TCGA patient cohorts, PLEKHG4B protein abundance is significantly associated with the RNA expression of many other genes, with 3,815 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLEKHG4B-associated genes across cancer lineages are RCOR2, RASAL2-AS1, and NEK11. Each is linked with PLEKHG4B in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHG4B-to-partner and partner-to-PLEKHG4B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHG4B versus RCOR2 in BRCA, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG4B→partner) and Y-score (partner→PLEKHG4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RCOR2 →	+1.397	+0.792	.002	.004	3	3
BRCA	RASAL2-AS1 →	+0.501	+0.956	<.001	<.001	3	3
LSCC	NEK11 →	+0.828	+0.647	<.001	<.001	3	2
BRCA	ARHGEF4 →	+1.117	+0.992	<.001	.001	3	2
LSCC	IFT172 →	+0.645	+0.711	<.001	.009	3	2
LSCC	ILF2 →	+1.015	+0.688	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,815 associations by consensus.

PLEKHG4B vs RCOR2 — BRCA

Explore this scatter interactively →