PLEKHG4B

Across TCGA pan-cancer cohorts, PLEKHG4B RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated PLEKHG4B data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PLEKHG4B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLEKHG4B expression acts as an unfavorable survival marker, although some lineages such as THYM and SCLC show a favorable association.

KIRC, UVM, and BLCA are the cancer types where PLEKHG4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.517	0.716	<.001	164	view →
UVM	DFS	Median	All	0.375	0.805	<.001	137	view →
BLCA	DFS	Median	All	0.267	0.425	<.001	84	view →
LGG	DFS	Median	All	0.303	0.481	<.001	54	view →
COAD	DFS	Tertile	All	0.390	0.663	.001	50	view →
ACC	DFS	Tertile	All	0.132	0.763	<.001	46	view →
SKCM	OS	Tertile	All	0.715	0.855	<.001	44	view →
UCEC	OS	Tertile	III,IV	0.783	0.911	.008	34	view →
STAD	DFS	Tertile	IV	0.101	0.585	.014	25	view →
THYM	OS	Tertile	All	0.948	0.718	.014	25	view →
MESO	DFS	Median	II,III,IV	0.297	0.504	.004	23	view →
SCLC	DFS	Median	II,III,IV	0.718	0.463	.012	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

PLEKHG4B–KIRC (DFS)

Open the KIRC breakdown →