PLEKHG4B

Across TCGA pan-cancer cohorts, PLEKHG4B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PLEKHG4B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PLEKHG4B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLEKHG4B is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where PLEKHG4B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLEKHG4B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.508	<.001	11	view →
KIRC	Male	II,III,IV	−1.215	<.001	11	view →
THCA	Male	IV	−2.706	<.001	10	view →
LUSC	Female	All	+1.790	<.001	6	view →
UCEC	All	All	+1.563	<.001	6	view →
KICH	Male	All	−1.543	<.001	6	view →
BLCA	All	All	+1.252	.002	5	view →
STAD	All	All	−0.262	.004	5	view →
LIHC	All	All	+0.065	.004	5	view →
COAD	Female	All	−0.079	.005	4	view →
CHOL	All	All	+2.018	.001	2	view →
LUAD	Female	All	+0.744	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PLEKHG4B–HNSC

Open the HNSC breakdown →