PLEKHG4B

Across TCGA patient cohorts, PLEKHG4B mutation is significantly associated with the RNA expression of many other genes, with 4,187 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHG4B-associated genes across cancer lineages are WDR76, FAM177A1, and CIAO2B. Each is linked with PLEKHG4B in more than 4 cancer types. Because this analysis shows association rather than direction, both PLEKHG4B-to-partner and partner-to-PLEKHG4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR76 grouped by PLEKHG4B-low versus PLEKHG4B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG4B→partner) and Y-score (partner→PLEKHG4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	WDR76 →	+0.600	+2.247	<.001	.001	3	5
SKCM	FAM177A1 →	+0.330	+1.421	.005	.006	3	4
UCEC	CIAO2B →	+0.313	+2.065	.001	<.001	3	4
UCEC	MAP2K1 →	+0.394	+1.970	.001	<.001	3	4
LUSC	SNUPN →	+0.353	+3.383	.006	.004	3	4
UCEC	CENPX →	+0.340	+1.684	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,187 associations by consensus.

WDR76 by PLEKHG4B expression — COAD

Explore this box plot interactively →