PLEKHG4B

Across TCGA patient cohorts, PLEKHG4B mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHG4B-associated genes across cancer lineages are eEF2, Caspase-7-cleavedD198, and ASNS. Each is linked with PLEKHG4B in more than 3 cancer types. Because this analysis shows association rather than direction, both PLEKHG4B-to-partner and partner-to-PLEKHG4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PLEKHG4B-low versus PLEKHG4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG4B→partner) and Y-score (partner→PLEKHG4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.290	+1.473	.007	.006	3	3
COAD	Caspase-7-cleavedD198 →	+1.231	+3.807	<.001	<.001	2	4
COAD	ASNS →	+0.558	+2.511	<.001	.001	3	3
COAD	CD49b →	+0.260	+3.186	.013	.009	3	3
UCEC	EGFR_pY1068 →	-0.300	-2.536	<.001	<.001	3	2
UCEC	MEK1 →	+0.330	+2.070	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

eEF2 by PLEKHG4B expression — UCEC

Explore this box plot interactively →