PLEKHG4B

Across TCGA cell cohorts, PLEKHG4B mutation is significantly associated with the RNA expression of many other genes, with 467 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHG4B-associated genes across cancer lineages are CEP192, C1QC, and NEU2. Each is linked with PLEKHG4B in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHG4B-to-partner and partner-to-PLEKHG4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP192 grouped by PLEKHG4B-low versus PLEKHG4B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG4B→partner) and Y-score (partner→PLEKHG4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CEP192 →	+0.558	+2.743	.003	.001	3	2
LUNG_NSCLC_LUSC	C1QC →	+0.013	+4.643	<.001	.008	3	1
SOFT_TISSUE	NEU2 →	+0.030	+3.297	.008	.008	3	1
SOFT_TISSUE	PGLYRP4 →	+0.010	+4.369	<.001	<.001	3	1
SOFT_TISSUE	KRTAP5-10 →	+0.038	+4.095	<.001	.003	3	1
SOFT_TISSUE	KRTAP3-2 →	+0.429	+3.295	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 467 associations by consensus.

CEP192 by PLEKHG4B expression — LARGE_INTESTINE

Explore this box plot interactively →