PLEKHF1

Across TCGA cell cohorts, PLEKHF1 mutation is significantly associated with the RNA expression of many other genes, with 129 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHF1-associated genes across cancer lineages are CST5, CYLC1, and FAM205C. Each is linked with PLEKHF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHF1-to-partner and partner-to-PLEKHF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST5 grouped by PLEKHF1-low versus PLEKHF1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHF1→partner) and Y-score (partner→PLEKHF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CST5 →	+0.134	+4.981	<.001	.008	3	2
CNS	CYLC1 →	+0.013	+5.321	<.001	.005	3	1
CNS	FAM205C →	+0.043	+4.981	<.001	.008	3	1
LARGE_INTESTINE	RAB3A →	+0.759	+3.451	.008	.002	3	1
LARGE_INTESTINE	SH3GL2 →	+1.483	+3.837	<.001	<.001	3	1
LARGE_INTESTINE	ATP5PB →	+0.513	+3.364	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 129 associations by consensus.

CST5 by PLEKHF1 expression — CNS

Explore this box plot interactively →