PLEKHF1

Across TCGA pan-cancer cohorts, PLEKHF1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PLEKHF1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLEKHF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLEKHF1 is over-expressed in tumor, although a few such as BRCA and PRAD show the opposite, repressed pattern.

KIRC, BRCA, and KIRP are the cancer types where PLEKHF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLEKHF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+1.167	<.001	12	view →
BRCA	All	II,III,IV	−1.083	<.001	8	view →
KIRP	All	All	+0.442	.012	4	view →
LIHC	Male	All	+0.762	.007	3	view →
KICH	All	All	+0.658	.024	3	view →
PRAD	All	All	−0.570	<.001	2	view →
HNSC	Male	IV	−0.733	.035	1	view →
LUSC	Female	All	−0.631	.041	1	view →
BLCA	Male	III,IV	−0.567	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PLEKHF1–KIRC

Open the KIRC breakdown →