PLEKHA8P1

Across TCGA patient cohorts, PLEKHA8P1 mutation is significantly associated with the RNA expression of many other genes, with 2,794 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHA8P1-associated genes across cancer lineages are PITHD1, TAF9, and NDUFA6. Each is linked with PLEKHA8P1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHA8P1-to-partner and partner-to-PLEKHA8P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PITHD1 grouped by PLEKHA8P1-low versus PLEKHA8P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA8P1→partner) and Y-score (partner→PLEKHA8P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PITHD1 →	+0.407	+3.524	.001	.002	3	3
UCEC	TAF9 →	+0.738	+3.828	<.001	<.001	3	2
COAD	NDUFA6 →	+0.592	+3.499	<.001	.002	3	2
COAD	RPS4X →	-0.499	-3.673	.002	.001	3	2
COAD	FCGR3A →	+1.266	+2.611	.003	.006	3	2
COAD	RNU1-2 →	+0.492	+2.242	.005	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,794 associations by consensus.

PITHD1 by PLEKHA8P1 expression — UCEC

Explore this box plot interactively →