PLEKHA8P1

Across TCGA pan-cancer cohorts, PLEKHA8P1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PLEKHA8P1 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PLEKHA8P1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLEKHA8P1 expression acts as an unfavorable survival marker, although some lineages such as THYM and THCA show a favorable association.

KIRC, CESC, and MESO are the cancer types where PLEKHA8P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.724	0.867	<.001	114	view →
CESC	DFS	Median	All	0.655	0.827	<.001	100	view →
MESO	OS	Median	All	0.274	0.504	<.001	93	view →
LIHC	OS	Median	All	0.682	0.861	<.001	91	view →
LUAD	OS	Tertile	All	0.251	0.487	<.001	87	view →
UVM	DFS	Tertile	II,III,IV	0.390	0.765	<.001	85	view →
HNSC	OS	Tertile	All	0.597	0.840	<.001	66	view →
KIRP	OS	Median	All	0.562	0.967	<.001	59	view →
LUSC	DFS	Tertile	II,III,IV	0.279	0.499	.001	57	view →
LGG	DFS	Median	All	0.653	0.823	<.001	53	view →
COAD	OS	Median	All	0.480	0.781	<.001	42	view →
KICH	DFS	Quartile	II,III,IV	0.570	1.000	.004	40	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PLEKHA8P1–KIRC (DFS)

Open the KIRC breakdown →