PLEKHA8P1

Across TCGA pan-cancer cohorts, PLEKHA8P1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PLEKHA8P1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PLEKHA8P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLEKHA8P1 is over-expressed in tumor, although a few such as BRCA and PRAD show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where PLEKHA8P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLEKHA8P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.204	<.001	12	view →
KIRC	Male	IV	+0.750	<.001	12	view →
COAD	Male	IV	+1.460	<.001	11	view →
LIHC	Female	II,III,IV	+1.085	<.001	9	view →
THCA	Male	All	+0.772	<.001	8	view →
KIRP	All	All	+0.394	.002	8	view →
BRCA	All	II,III,IV	−0.726	<.001	6	view →
CHOL	Male	All	+1.685	<.001	5	view →
READ	All	All	+1.217	<.001	5	view →
STAD	All	II,III,IV	+0.631	.001	4	view →
PRAD	All	All	−0.526	<.001	2	view →
LUAD	Male	II,III,IV	+0.473	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PLEKHA8P1–HNSC

Open the HNSC breakdown →