PLEKHA8P1

Across TCGA patient cohorts, PLEKHA8P1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PLEKHA8P1-associated genes across cancer lineages are ERK2, GSK3-a-b, and PDCD4. Each is linked with PLEKHA8P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHA8P1-to-partner and partner-to-PLEKHA8P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PLEKHA8P1-low versus PLEKHA8P1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA8P1→partner) and Y-score (partner→PLEKHA8P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ERK2 →	+0.194	+2.195	.033	.034	3	2
COAD	GSK3-a-b →	+0.172	+2.212	.016	.033	3	2
UCEC	PDCD4 →	-0.774	-2.807	<.001	.003	3	2
COAD	PKC-b-II_pS660 →	-0.438	-3.000	.008	.035	3	2
COAD	Bad_pS112 →	-0.284	-3.313	.002	.010	3	2
COAD	CD49b →	+0.412	+3.330	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ERK2 by PLEKHA8P1 expression — COAD

Explore this box plot interactively →