PLEKHA8

Across TCGA patient cohorts, PLEKHA8 mutation is significantly associated with the RNA expression of many other genes, with 1,271 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHA8-associated genes across cancer lineages are RNU4-58P, LINC01326, and SNRPGP17. Each is linked with PLEKHA8 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHA8-to-partner and partner-to-PLEKHA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by PLEKHA8-low versus PLEKHA8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA8→partner) and Y-score (partner→PLEKHA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-58P →	+0.215	+2.648	<.001	.002	3	3
COAD	LINC01326 →	+0.644	+6.122	<.001	.002	3	3
UCEC	SNRPGP17 →	+0.205	+1.727	.008	.009	3	2
COAD	ATXN3L →	+0.412	+6.721	<.001	<.001	3	2
COAD	TRIM48 →	+0.484	+6.392	<.001	.001	3	2
PRAD	RNU6-1060P →	+0.568	+7.939	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,271 associations by consensus.

RNU4-58P by PLEKHA8 expression — UCEC

Explore this box plot interactively →