PLEKHA8

Across TCGA pan-cancer cohorts, PLEKHA8 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PLEKHA8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PLEKHA8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLEKHA8 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where PLEKHA8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLEKHA8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.997	<.001	12	view →
BLCA	All	III,IV	+0.838	<.001	11	view →
COAD	Male	IV	+1.132	<.001	10	view →
LUAD	Male	II,III,IV	+1.248	<.001	9	view →
LIHC	Male	II,III,IV	+0.895	<.001	9	view →
LUSC	Male	II,III,IV	+0.932	<.001	8	view →
STAD	Male	II,III,IV	+0.893	<.001	8	view →
UCEC	All	II,III,IV	+1.135	<.001	6	view →
BRCA	All	II,III,IV	+0.473	<.001	6	view →
CHOL	Female	All	+1.766	<.001	3	view →
READ	All	All	+0.778	.002	3	view →
PRAD	All	All	+0.214	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PLEKHA8–HNSC

Open the HNSC breakdown →