PLCZ1

Across TCGA patient cohorts, PLCZ1 mutation is significantly associated with the RNA expression of many other genes, with 4,059 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCZ1-associated genes across cancer lineages are EIF2B2, DHX30, and OR5J7P. Each is linked with PLCZ1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLCZ1-to-partner and partner-to-PLCZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF2B2 grouped by PLCZ1-low versus PLCZ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCZ1→partner) and Y-score (partner→PLCZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF2B2 →	+0.405	+3.042	<.001	<.001	3	3
UCEC	DHX30 →	+0.360	+2.338	.003	.003	3	3
SKCM	OR5J7P →	+0.012	+2.160	<.001	.007	3	3
UCEC	RPL23AP7 →	+0.370	+3.040	.001	<.001	3	3
SKCM	CNTROB →	+0.252	+0.935	<.001	.008	3	3
SCLC	MCHR2 →	+0.351	+4.847	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,059 associations by consensus.

EIF2B2 by PLCZ1 expression — UCEC

Explore this box plot interactively →