PLCZ1

Across TCGA pan-cancer cohorts, PLCZ1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PLCZ1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLCZ1 RNA is repressed in tumor relative to normal tissue. In most cancer types PLCZ1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and BRCA are the cancer types where PLCZ1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLCZ1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−0.270	<.001	12	view →
KIRP	Male	All	−0.264	<.001	11	view →
BRCA	Female	All	−0.631	<.001	6	view →
LIHC	All	II,III,IV	−0.066	.013	5	view →
LUSC	All	All	+0.117	.002	4	view →
READ	All	III,IV	−0.035	.019	3	view →
STAD	Female	All	−0.161	.001	2	view →
CHOL	All	All	−0.131	.001	2	view →
PRAD	All	All	−0.093	<.001	2	view →
HNSC	All	III,IV	+0.066	.024	2	view →
ESCA	All	All	−0.533	.047	1	view →
LUAD	All	All	+0.122	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PLCZ1–KIRC

Open the KIRC breakdown →