Across TCGA cell cohorts, PLCG2 mutation is significantly associated with the RNA expression of many other genes, with 284 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCG2-associated genes across cancer lineages are OPRM1, FAM149A, and C1QTNF7. Each is linked with PLCG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCG2-to-partner and partner-to-PLCG2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCG2→partner) and Y-score (partner→PLCG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OPRM1 →	+0.014	+3.536	.001	.001	3	2
LARGE_INTESTINE	FAM149A →	+1.121	+2.158	.001	.004	3	2
LARGE_INTESTINE	C1QTNF7 →	+0.049	+2.038	.003	.009	3	2
KIDNEY	STMN2 →	+0.111	+3.321	.003	.008	2	2
KIDNEY	MYOD1 →	+0.041	+3.369	<.001	.003	3	1
KIDNEY	GADL1 →	+0.042	+3.807	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 284 associations by consensus.

Exploration

PLCG2 survival (RNA) · tumor vs normal (RNA) · all PLCG2 data types