PLCD3

Across TCGA patient cohorts, PLCD3 mutation is significantly associated with the RNA expression of many other genes, with 2,635 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCD3-associated genes across cancer lineages are PGAM1P9, ZNHIT3, and MIR4734. Each is linked with PLCD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLCD3-to-partner and partner-to-PLCD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGAM1P9 grouped by PLCD3-low versus PLCD3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCD3→partner) and Y-score (partner→PLCD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PGAM1P9 →	+0.039	+3.435	<.001	.007	3	3
UCEC	ZNHIT3 →	+0.373	+2.297	.003	.004	3	2
SKCM	MIR4734 →	+0.283	+2.949	<.001	.005	3	2
HNSC	MBD3L4 →	+0.059	+7.954	<.001	.008	3	2
CESC	NTF6A →	+0.051	+4.384	<.001	.008	3	2
CESC	TRAJ20 →	+0.494	+3.760	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,635 associations by consensus.

PGAM1P9 by PLCD3 expression — BLCA

Explore this box plot interactively →