PLCB2

Across TCGA cell cohorts, PLCB2 mutation is significantly associated with the RNA expression of many other genes, with 105 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PLCB2-associated genes across cancer lineages are C16orf92, VN1R2, and PGLYRP4. Each is linked with PLCB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCB2-to-partner and partner-to-PLCB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf92 grouped by PLCB2-low versus PLCB2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCB2→partner) and Y-score (partner→PLCB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C16orf92 →	+0.198	+4.037	<.001	.004	3	2
BLOOD_Lymphoma	VN1R2 →	+0.009	+4.643	<.001	.005	3	2
SOFT_TISSUE	PGLYRP4 →	+0.016	+5.369	<.001	.004	3	1
SOFT_TISSUE	FOXI2 →	+0.006	+4.930	<.001	.008	3	1
SOFT_TISSUE	FAM205C →	+0.070	+4.930	<.001	.008	3	1
SOFT_TISSUE	TARM1 →	+0.024	+5.369	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

C16orf92 by PLCB2 expression — BLOOD_Leukemia

Explore this box plot interactively →