PLAAT4

Across TCGA patient cohorts, PLAAT4 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLAAT4-associated genes across cancer lineages are ERK2, JNK_pT183_Y185, and Rab25. Each is linked with PLAAT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAAT4-to-partner and partner-to-PLAAT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PLAAT4-low versus PLAAT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAAT4→partner) and Y-score (partner→PLAAT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.269	+3.169	.011	.019	2	1
UCEC	JNK_pT183_Y185 →	-0.223	-3.156	.016	.020	1	1
UCEC	Rab25 →	-0.479	-3.169	.008	.020	1	1
UCEC	VHL →	-1.463	-3.169	<.001	.020	1	1
UCEC	ATM →	-0.548	-3.169	.027	.020	1	1
UCEC	Caspase-7-cleavedD198 →	+0.926	+3.169	.004	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ERK2 by PLAAT4 expression — UCEC

Explore this box plot interactively →