PLAAT4

Across TCGA pan-cancer cohorts, PLAAT4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PLAAT4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLAAT4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLAAT4 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, LUSC, and KICH are the cancer types where PLAAT4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLAAT4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.662	<.001	11	view →
LUSC	Male	II,III,IV	−2.201	<.001	8	view →
KICH	Male	All	+1.805	<.001	6	view →
BRCA	All	III,IV	+1.346	<.001	6	view →
LUAD	Male	II,III,IV	−1.169	.004	6	view →
UCEC	All	All	−1.126	.003	6	view →
KIRP	Male	All	+1.006	<.001	6	view →
ESCA	All	All	+1.851	.021	4	view →
STAD	All	III,IV	+1.392	.009	4	view →
COAD	All	All	−0.728	.013	4	view →
THCA	Male	II,III,IV	+0.924	.016	3	view →
READ	Female	All	−1.471	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PLAAT4–KIRC

Open the KIRC breakdown →