PLAAT4

Across TCGA pan-cancer cohorts, PLAAT4 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PLAAT4 data layer compared with 3 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PLAAT4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PLAAT4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

SKCM, CESC, and MESO are the cancer types where PLAAT4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.430	0.250	<.001	150	view →
CESC	OS	Tertile	All	0.891	0.681	<.001	124	view →
MESO	OS	Median	All	0.493	0.283	<.001	117	view →
BRCA	DFS	Median	All	0.934	0.870	<.001	102	view →
PAAD	DFS	Median	All	0.258	0.450	<.001	88	view →
LGG	DFS	Median	All	0.292	0.475	<.001	40	view →
SARC	OS	Median	All	0.840	0.647	<.001	34	view →
LAML	DFS	Tertile	All	0.284	0.663	.001	30	view →
ESCA	OS	Quartile	All	0.323	1.000	.006	30	view →
HNSC	DFS	Tertile	All	0.688	0.538	.005	26	view →
THYM	DFS	Tertile	II,III,IV	0.548	0.913	.011	16	view →
GBM	OS	Tertile	All	0.313	0.546	.007	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

PLAAT4–SKCM (OS)

Open the SKCM breakdown →