Across TCGA cell cohorts, PLA2G4E mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLA2G4E-associated genes across cancer lineages are VWC2L, OR56A5, and CYP2A13. Each is linked with PLA2G4E in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G4E-to-partner and partner-to-PLA2G4E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G4E→partner) and Y-score (partner→PLA2G4E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VWC2L →	+0.009	+3.339	<.001	.006	3	1
BLOOD_Leukemia	OR56A5 →	+0.021	+4.569	<.001	.003	3	1
BLOOD_Leukemia	CYP2A13 →	+0.006	+4.569	<.001	.003	3	1
SKIN	SERPINA4 →	+0.005	+3.930	<.001	.003	3	1
SKIN	ZIC3 →	+0.178	+3.969	<.001	.004	3	1
SKIN	OR14A16 →	+0.018	+5.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

PLA2G4E survival (RNA) · tumor vs normal (RNA) · all PLA2G4E data types