PLA2G4A

Across TCGA patient cohorts, PLA2G4A mutation is significantly associated with the RNA expression of many other genes, with 3,996 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G4A-associated genes across cancer lineages are C4orf46, VRK1, and RFC5. Each is linked with PLA2G4A in more than 3 cancer types. Because this analysis shows association rather than direction, both PLA2G4A-to-partner and partner-to-PLA2G4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C4orf46 grouped by PLA2G4A-low versus PLA2G4A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G4A→partner) and Y-score (partner→PLA2G4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	C4orf46 →	+0.750	+3.204	<.001	.009	3	4
UCEC	VRK1 →	+0.452	+2.078	.004	<.001	3	4
UCEC	RFC5 →	+0.447	+2.008	<.001	.001	3	4
UCEC	PSMC3IP →	+0.623	+1.818	<.001	<.001	3	4
UCEC	CISD2 →	+0.453	+3.004	<.001	<.001	3	4
SKCM	CENPL →	+0.511	+3.397	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,996 associations by consensus.

C4orf46 by PLA2G4A expression — LUAD

Explore this box plot interactively →