PLA2G4A

Across TCGA pan-cancer cohorts, PLA2G4A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PLA2G4A data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PLA2G4A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLA2G4A expression acts as an unfavorable survival marker, although some lineages such as UCEC and KIRC show a favorable association.

UVM, UCEC, and LAML are the cancer types where PLA2G4A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.498	0.883	.001	75	view →
UCEC	DFS	Tertile	All	0.932	0.853	.001	72	view →
LAML	DFS	Median	All	0.210	0.550	<.001	54	view →
LGG	OS	Median	All	0.369	0.545	<.001	50	view →
KIRC	DFS	Quartile	II,III,IV	0.862	0.551	.003	48	view →
HNSC	OS	Median	IV	0.719	0.557	.005	42	view →
LUAD	DFS	Tertile	III,IV	0.425	0.819	.001	36	view →
CHOL	DFS	Tertile	All	0.759	0.257	.012	30	view →
BRCA	DFS	Tertile	All	0.596	0.441	.004	24	view →
READ	DFS	Median	III,IV	0.324	0.673	.001	20	view →
STAD	DFS	Median	IV	0.212	0.560	.020	9	view →
PAAD	DFS	Tertile	II,III,IV	0.550	0.342	.025	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PLA2G4A–UVM (DFS)

Open the UVM breakdown →