PLA2G4A

Across TCGA pan-cancer cohorts, PLA2G4A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PLA2G4A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLA2G4A RNA is repressed in tumor relative to normal tissue. In most cancer types PLA2G4A is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LUAD are the cancer types where PLA2G4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLA2G4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.568	<.001	12	view →
KICH	All	All	−1.539	<.001	9	view →
LUAD	Female	All	+1.917	<.001	8	view →
THCA	Female	II,III,IV	−1.155	<.001	8	view →
BRCA	All	III,IV	−2.243	<.001	6	view →
PAAD	All	All	+1.032	.019	4	view →
HNSC	Male	All	+0.834	.004	4	view →
PRAD	All	All	−1.119	<.001	2	view →
KIRP	All	All	−0.616	.003	2	view →
LIHC	Male	All	−0.351	.002	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PLA2G4A–KIRC

Open the KIRC breakdown →