PLA2G4A

Across TCGA patient cohorts, PLA2G4A mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G4A-associated genes across cancer lineages are MIG-6, Cyclin-B1, and Caspase-7-cleavedD198. Each is linked with PLA2G4A in more than 2 cancer types. Because this analysis shows association rather than direction, both PLA2G4A-to-partner and partner-to-PLA2G4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by PLA2G4A-low versus PLA2G4A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G4A→partner) and Y-score (partner→PLA2G4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIG-6 →	+0.221	+3.000	.045	.036	3	3
UCEC	Cyclin-B1 →	+0.672	+2.415	<.001	.003	3	3
COAD	Caspase-7-cleavedD198 →	+1.293	+2.815	.002	.036	3	3
COAD	C-Raf →	+0.266	+2.815	<.001	.036	3	3
UCEC	eEF2 →	+0.395	+2.807	<.001	.002	3	3
UCEC	PCNA →	+0.252	+2.115	<.001	.016	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

MIG-6 by PLA2G4A expression — LUAD

Explore this box plot interactively →