PLA2G4A

Across TCGA cell cohorts, PLA2G4A mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLA2G4A-associated genes across cancer lineages are CD300H, SLC26A3, and OR51T1. Each is linked with PLA2G4A in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G4A-to-partner and partner-to-PLA2G4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD300H grouped by PLA2G4A-low versus PLA2G4A-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G4A→partner) and Y-score (partner→PLA2G4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CD300H →	+0.207	+3.874	.001	.006	3	1
CNS	SLC26A3 →	+0.049	+3.975	<.001	.005	3	1
BLOOD_Leukemia	OR51T1 →	+0.064	+4.507	<.001	.001	3	1
BLOOD_Leukemia	TAFA1 →	+0.606	+4.149	.003	.003	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1
BLOOD_Leukemia	PRSS50 →	+0.034	+4.066	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

CD300H by PLA2G4A expression — CNS

Explore this box plot interactively →