PLA2G3

Across TCGA patient cohorts, PLA2G3 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,103 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible PLA2G3-associated GO terms across cancer lineages are Regulation of histamine secretion by mast cell, Histamine secretion, and Isopentenyl diphosphate biosynthetic process. Each is linked with PLA2G3 in more than 14 cancer types. Because this analysis shows association rather than direction, both PLA2G3-to-partner and partner-to-PLA2G3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of histamine secretion by mast cell grouped by PLA2G3-low versus PLA2G3-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G3→partner) and Y-score (partner→PLA2G3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of histamine secretion by mast cell →	-0.079	-1.277	<.001	<.001	3	15
STAD	Histamine secretion →	-0.063	-0.811	<.001	<.001	3	14
ESCA	Isopentenyl diphosphate biosynthetic process →	+0.046	+1.150	<.001	<.001	3	14
TGCT	Sterol biosynthetic process →	+0.026	+0.404	<.001	<.001	3	12
ESCA	Histamine transport →	-0.054	-0.946	<.001	<.001	2	13
TGCT	Acetyl-CoA metabolic process →	+0.030	+0.334	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,103 associations by consensus.

Regulation of histamine secretion by mast cell by PLA2G3 expression — ESCA

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