PLA2G3

Across TCGA patient cohorts, PLA2G3 mutation is significantly associated with the RNA expression of many other genes, with 3,433 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G3-associated genes across cancer lineages are MIR409, SNORD114-7, and NPAP1P2. Each is linked with PLA2G3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G3-to-partner and partner-to-PLA2G3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR409 grouped by PLA2G3-low versus PLA2G3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G3→partner) and Y-score (partner→PLA2G3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR409 →	+0.317	+5.309	<.001	.003	3	2
LUSC	SNORD114-7 →	+0.558	+5.081	<.001	.004	3	2
LUSC	NPAP1P2 →	+0.075	+4.503	.001	.005	3	2
HNSC	HSD17B7P1 →	+0.052	+5.182	<.001	.007	3	2
HNSC	RPSAP35 →	+0.097	+5.303	<.001	.006	3	2
BLCA	KRTAP3-4P →	+0.283	+6.289	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,433 associations by consensus.

MIR409 by PLA2G3 expression — LUSC

Explore this box plot interactively →