PLA2G3

Across TCGA patient cohorts, PLA2G3 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G3-associated genes across cancer lineages are Akt_pT308, Caspase-7-cleavedD198, and FASN. Each is linked with PLA2G3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLA2G3-to-partner and partner-to-PLA2G3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by PLA2G3-low versus PLA2G3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G3→partner) and Y-score (partner→PLA2G3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.601	+1.700	.012	.040	3	3
UCEC	Caspase-7-cleavedD198 →	+0.695	+2.720	.002	.003	3	3
UCEC	FASN →	+0.354	+1.678	.019	.023	3	2
UCEC	AMPK_pT172 →	+0.313	+1.335	.047	.046	3	2
UCEC	VHL →	-0.918	-2.115	<.001	.016	3	2
UCEC	XBP1 →	-0.180	-1.687	<.001	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Akt_pT308 by PLA2G3 expression — UCEC

Explore this box plot interactively →