Q-omics provides the consensus-scored PKP4-AS1 profile across patient tissues and cancer cell-line models. PKP4-AS1 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in LUSC. Among the 18 cancer types available for tumor–normal comparison, PKP4-AS1 is differentially expressed in 15, with the highest sampling consensus in COAD. Additionally, PKP4-AS1 RNA expression shows 18,394 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight LUSC, COAD, and GBM as cancer lineages where PKP4-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PKP4-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PKP4-AS1 survival associations across molecular data types. PKP4-AS1 RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PKP4-AS1 RNA expression–survival associations across cancer types. High PKP4-AS1 expression shows unfavorable associations in COAD, MESO, CHOL and STAD, but favorable associations in LUSC and CESC. The LUSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUSC as the clearest survival context for PKP4-AS1 RNA expression.
This table summarizes PKP4-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for PKP4-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PKP4-AS1 shows lower tumor expression in KICH and higher tumor expression in COAD, LUSC, LUAD, LIHC and UCEC. The COAD box plot shows higher PKP4-AS1 RNA expression in tumor versus normal tissue (log2 FC = +0.169, t-test p < 0.001).
This table shows molecular features associated with PKP4-AS1 in patient tissues and cancer cell lines. In patient samples, PKP4-AS1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
