PKN3

Across TCGA patient cohorts, PKN3 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKN3-associated genes across cancer lineages are ERK2, JNK2, and Ku80. Each is linked with PKN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKN3-to-partner and partner-to-PKN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PKN3-low versus PKN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKN3→partner) and Y-score (partner→PKN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.243	+3.321	.006	.009	3	1
UCEC	JNK2 →	+0.312	+3.009	<.001	.019	2	2
UCEC	Ku80 →	+0.229	+1.887	.038	.031	3	1
UCEC	VEGFR2 →	+0.309	+1.887	.025	.031	3	1
UCEC	BRCA2 →	-0.126	-2.452	.039	.020	3	1
UCEC	ATM →	-0.585	-2.584	.005	.011	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ERK2 by PKN3 expression — UCEC

Explore this box plot interactively →