PKN3

Across TCGA pan-cancer cohorts, PKN3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PKN3 data layer compared with 9 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher PKN3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PKN3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

MESO, ACC, and UVM are the cancer types where PKN3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.402	0.682	<.001	144	view →
ACC	DFS	Median	All	0.229	0.673	<.001	112	view →
UVM	DFS	Tertile	All	0.401	0.783	<.001	87	view →
SKCM	OS	Median	All	0.266	0.404	<.001	61	view →
LGG	DFS	Median	All	0.330	0.503	<.001	50	view →
KIRC	DFS	Median	All	0.876	0.721	<.001	43	view →
KIRP	OS	Tertile	III,IV	0.211	0.716	.004	35	view →
HNSC	DFS	Tertile	IV	0.735	0.562	.004	33	view →
COAD	DFS	Median	III,IV	0.517	0.771	.001	31	view →
BLCA	DFS	Quartile	III,IV	0.464	0.611	.016	21	view →
GBM	DFS	Tertile	All	0.342	0.187	.001	21	view →
LIHC	DFS	Median	All	0.481	0.597	.007	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PKN3–MESO (OS)

Open the MESO breakdown →