PKLR

Across TCGA patient cohorts, PKLR mutation is significantly associated with the RNA expression of many other genes, with 1,844 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKLR-associated genes across cancer lineages are MICE, ZCCHC10, and CARNMT1. Each is linked with PKLR in more than 2 cancer types. Because this analysis shows association rather than direction, both PKLR-to-partner and partner-to-PKLR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MICE grouped by PKLR-low versus PKLR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKLR→partner) and Y-score (partner→PKLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MICE →	+0.389	+2.028	<.001	.002	3	3
UCEC	ZCCHC10 →	+0.333	+2.946	.007	<.001	3	3
UCEC	CARNMT1 →	+0.407	+2.338	.009	.003	3	3
UCEC	KATNAL2 →	-0.504	-2.071	.005	.005	3	3
UCEC	ZNF57 →	+0.319	+2.008	.003	.005	3	3
UCEC	FAS →	+0.657	+1.895	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,844 associations by consensus.

MICE by PKLR expression — UCEC

Explore this box plot interactively →