PKLR

Across TCGA pan-cancer cohorts, PKLR RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PKLR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where PKLR RNA is repressed in tumor relative to normal tissue. In most cancer types PKLR is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and CHOL are the cancer types where PKLR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PKLR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−2.976	<.001	11	view →
KICH	Male	II,III,IV	−4.024	<.001	8	view →
CHOL	All	All	−5.076	<.001	5	view →
LUSC	All	All	+0.176	<.001	5	view →
BRCA	All	II,III,IV	+0.040	.010	4	view →
HNSC	Male	III,IV	+0.231	.023	2	view →
BLCA	Male	All	+0.093	.037	2	view →
LUAD	All	All	+0.030	.023	2	view →
LIHC	Male	All	+0.608	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PKLR–KIRP

Open the KIRP breakdown →