PKDCC

Across TCGA patient cohorts, PKDCC mutation is significantly associated with the RNA expression of many other genes, with 1,079 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKDCC-associated genes across cancer lineages are RNU4-58P, RNU1-57P, and RNA5SP266. Each is linked with PKDCC in more than 1 cancer types. Because this analysis shows association rather than direction, both PKDCC-to-partner and partner-to-PKDCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by PKDCC-low versus PKDCC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKDCC→partner) and Y-score (partner→PKDCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-58P →	+0.202	+2.811	.004	.004	3	2
UCEC	RNU1-57P →	+0.194	+3.885	<.001	.008	3	2
UCEC	RNA5SP266 →	+0.258	+4.475	<.001	.003	3	2
UCEC	RNU7-29P →	+0.262	+3.847	<.001	.001	3	2
UCEC	OR11J5P →	+0.020	+4.893	<.001	.001	3	2
SKCM	RNU6-528P →	+0.254	+4.970	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,079 associations by consensus.

RNU4-58P by PKDCC expression — UCEC

Explore this box plot interactively →