PKDCC

Across TCGA pan-cancer cohorts, PKDCC RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PKDCC data layer compared with 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PKDCC RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PKDCC expression acts as an unfavorable survival marker, although some lineages such as UCEC and UCS show a favorable association.

UCEC, MESO, and BLCA are the cancer types where PKDCC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	0.775	0.464	<.001	94	view →
MESO	OS	Median	All	0.269	0.503	<.001	70	view →
BLCA	DFS	Tertile	All	0.570	0.735	.002	40	view →
THCA	OS	Median	III,IV	0.944	1.000	.003	40	view →
UCS	DFS	Median	II,III,IV	0.608	0.269	.004	22	view →
COAD	OS	Tertile	All	0.733	0.856	.008	19	view →
DLBC	OS	Median	III,IV	1.000	0.344	.024	16	view →
CHOL	DFS	Median	IV	0.858	0.339	.017	12	view →
LUAD	DFS	Quartile	All	0.577	0.732	.003	10	view →
LIHC	OS	Quartile	II,III,IV	0.407	0.734	.008	10	view →
PRAD	DFS	Median	All	0.907	0.958	.009	10	view →
ESCA	OS	Median	All	0.449	1.000	.011	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PKDCC–UCEC (DFS)

Open the UCEC breakdown →