Across TCGA patient cohorts, PIWIL3 mutation is significantly associated with the RNA expression of many other genes, with 3,440 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIWIL3-associated genes across cancer lineages are NPLP1, PACSIN2, and THAP7. Each is linked with PIWIL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIWIL3-to-partner and partner-to-PIWIL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIWIL3→partner) and Y-score (partner→PIWIL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	NPLP1 →	+0.291	+5.421	<.001	.005	3	3
UCEC	PACSIN2 →	+0.491	+2.606	<.001	<.001	3	3
UCEC	THAP7 →	+0.243	+2.141	.009	.002	3	3
UCEC	RNA5SP413 →	+0.811	+1.402	<.001	.007	3	3
BLCA	LINC00459 →	+0.080	+4.433	.001	.007	3	3
CESC	TRDJ2 →	+1.000	+3.556	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,440 associations by consensus.

Exploration

PIWIL3 survival (RNA) · tumor vs normal (RNA) · all PIWIL3 data types