Across TCGA pan-cancer cohorts, PIWIL3 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PIWIL3’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PIWIL3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIWIL3 is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.

BLCA, LUAD, and LUSC are the cancer types where PIWIL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIWIL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.355	.041	2	view →
LUAD	All	All	+0.184	.045	1	view →
LUSC	Female	All	+0.077	.037	1	view →
ESCA	Female	All	−0.020	.025	1	view →
LIHC	Female	All	+0.006	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: PIWIL3 RNA expression & survival · all PIWIL3 data types